Class of chemical compounds formally derived from ammonia by replacing three hydrogen atoms by organyl groups.
1
NH3; NH2R; NHR2; NR3; Ammonia; primary amine; secondary amine; tertiary amine; NR4I.
2
The quaternary ammonium linker represents a significant advance in linker technology, enabling stable conjugation of payloads with tertiary amine residues.
3
The tertiary amine is then distilled off, the residual products separated by filtration and finally hydrolysed by a caustic alkali.
4
External to the aromatic site, there is another weaker and less gating-dependent site for the tertiary amine chain in the latter two drugs.
5
The quaternary ammonium linker was then applied to a tubulysin antimitotic drug that contained an N-terminal tertiary amine that was important for activity.
1
The secondary and tertiary amines do not give this reaction.
2
When heated with alkyl or aryl iodides, they are converted into secondary and tertiary amines.
3
The mixed tertiary amines are produced by the action of alkyl halides on the primary amines.
4
The tertiary amines may also be of two types, the purely aromatic and the mixed type.
5
A new carbamoylation of tertiary amines is reported.
6
The primary, secondary and tertiary amines may be readily distinguished by their behaviour with various reagents.
7
The tertiary amines possess the power of combining with one molecular proportion of an alkyl iodide to form quaternary ammonium salts.